About Us. Advances in Pharmacological and Pharmaceutical Sciences is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of experimental and clinical pharmacology, pharmaceutics, medicinal chemistry and drug delivery.Topics covered by the journal include, but are not limited to:-Biochemical pharmacology, drug mechanism . Medications don't act in the same route in all people, and patientto-quiet variability in medication reaction is exceptionally regular. Impact Factor 2010 Quartile of the Impact Factor (1 best, 4 the lowest) . It is used for the therapeutic benefit of patient. 1166/ jbn. In a study, indocyanine green (ICG), a potent, . Sci.) 14193 61, https:// doi. In recent years, NPs such as liposomes, dendrimers, ). org/ 10. jconr el. . However, hyperosmotic disruption coupled with an applied external magnetic field significantly enhanced the permeability of Sali-IONPs across bEnd.3 monolayers (3.2% 0.1%) and reduced the viability of U251 cells to 38%. Search Google Scholar for this author. https:// doi. Share . SLPs) were prepared in the presence of oleic acid-coated iron oxide (IO-OA) nanoparticles with 1-tetradecanol and poly(ethylene oxide)-block-poly(-caprolactone) as lipid and stabilizing surfactant-like agents, respectively. ). org/ 10. Article Type. Advances in Pharmaceutical Science Research, 2013, Vol. Due to their relatively high molecular weight, most therapeutic drugs fail to cross the BBB from the blood circulation. The availability of narrow therapeutic choices for GBM management adds to the irony, even the post-treatment median survival time is roughly around 14-16 months. 2008. To finish, recent studies that have used lipidbased nanosystems carrying not only therapeutic agents, yet also magnetic nanoparticles are described. The study of the physical and chemical properties of drugs and their properties and drug dosage as related to the onset of action of a drug, duration, and intensity of drug action. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. Journal of Pharmacy and Pharmaceutical Sciences 1482-1826 Current Oncology 1198-0052 Korean Journal of Radiology 1229-6929 . Bioavailability alludes to the degree and rate at which the dynamic moiety (medication or metabolite) enters systemic flow, in this manner getting to the site of activity. Pharmacognosy deals especially with medicinal substances obtained from plants. These data show that BBB efflux by P-gp and BCRP is therefore an important determinant in both brain penetrance and molecular targeting efficacy in the treatment of invasive glioma cells. org/ 10. This book is a highly valuable resource for a range of demographics, including academic researchers and the pharmaceutical industry, providing a comprehensive inventory detailing the current and future applications of 3D printing in org/ 10. Journals Related to Drug Delivery Systems, Journal of Membrane Science & Technology, Journal of Pharmaceutics & Drug Delivery Research, Biochemical Pharmacology, Pharmaceutical Research, Pharmacology and Therapeutics. 2018. Glioma is the most common intracranial malignant tumor, and its specific pathogenesis has been unclear, which has always been an unresolved clinical problem due to the limited therapeutic window of glioma. 1965, https:// doi. 1155/ 2019/ 37025 18, https:// doi. Medications have long been utilized to enhance wellbeing and expand lives. Brain tumor penetrance of GDC-0980 and GNE-317 was compared between FVB/n wild-type mice and Mdr1a/b(-/-)Bcrp(-/-) triple-knockout mice lacking P-gp and BCRP. Designing of novel 6(H)-1,3,4-thiadiazine derivatives as MMP12 inhibitors : A As proof-of-principle, the biodistribution, tolerability, and efficacy of the nanocarriers were assessed, the latter in GB-bearing mice through magnetic resonance imaging and spectroscopy. That is the invention in medical history in order to yield significant therapeutic response. Although the advantages of using this type of nanosystems are explained including their biocompatibility, the possibility of modifying their surface to enhance the cell targeting, and their intrinsic ability of BBB crossing it is important to mention that research in this field is still at its early stage, and extensive preclinical and clinical investigations are mandatory in the close future. 1038/ sj. Any contributio n is important for the Scientific Community. J. Pharm. 1016/j. Side Effects of Drugs Annual, Journal of Clinical Toxicology, Annals of Pharmacotherapy, Biological and Pharmaceutical Bulletin, Journal of Pharmacy and Pharmacology. Advances in Biocatalytic Synthesis, Pharmacological Activities, Pharmaceutical Preparation and Metabolism of Ginsenoside Rh2 Li Liu, Huiyun Wang, Xiaoyun Chai*, Qingguo Meng*, Sheng Jiang and Fenglan Zhao DOI: 10.2174/1389557521666210913114631 014. https:// doi. 00205. https:// doi. Lipidpolymer hybrid, ). A Condition or symptom where to give a indication against the advisability or to give advice against a treatment. Journal of Pharmaceutical Microbiology is a Science journal that publishes articles based on original research on basic and clinical sciences related to Pharmaceutical Microbiology. plipr es. 1016/j. The gene editing efficiency and drug sensitivity changes were evaluated both in vitro and in vivo. Peer Reviewed Articles Very Recently Published in this Journal, Journal of Pharmaceutical Sciences & Emerging Drugs received 270 citations as per google scholar report. 03. S2241 60. It embody live population primarily based benefits and risks of drug in large numbers of individuals. Gold nanoparticles (AuNPs) due to their biocompatibility and tunable optical properties have widely been utilized for an assortment of theranostic purposes. Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug 131(4): p. 233-240. Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. 1347-8613: 1347-8648: Journal of Pharmacological Sciences 0022-3565 : 1521-0103 : Journal of Pharmacology and Experimental Therapeutics 0022-3573 : 2042-7158 : Journal of Pharmacy and Pharmacology Journals Related to Drug Design & Development, Drug Design, Development and Therapy, International Journal of Drug Development and Research, International Journal of Drug Design and Discovery, Journal of Developing Drugs. Furthermore, the FUS-assisted MBs-LPHNspCas9/MGMT-cRGD enhanced the therapeutic effects of TMZ in glioblastoma, inhibited tumor growth, and prolonged survival of tumor-bearing mice, with a high level of biosafety. 2266, https:// doi. Side Effects of Drugs Annual,Side Effects of Drugs Annual, Journal of Clinical Toxicology, Journal of Psychopharmacology, Clinical and Experimental Pharmacology and Physiology. Salinomycin is an antibiotic introduced recently as a new and effective anticancer drug. Journal emphasises on all aspects of the pharmaceutical sciences which includes a wide range of fields in its discipline like Pharmacology . Pharmaceutics is a branch of pharmacy which deals with formulation, compounding, dispensing, of the pharmaceutical ingredient. These findings suggest that Sali-IONPs combined with penetration enhancers, such as hyperosmotic mannitol and external magnetic fields, can potentially provide effective and site-specific magnetic targeting for GBM chemotherapy. It is the study of body reaction to the drug. Asian Journal of Chemistry; Vol. Pharmacokinetics is the study of absorption, distribution, metabolism, and excretion of drugs. Nanotechnology is a multidisciplinary field where the joining of fundamental sciences and connected controls like biophysics, molecular science, and bioengineering. org/ 10. SLNs and NLCs have been described as superior can, ). ), the official journal of the Korean Society of Pharmaceutical Sciences and Technology, is an international, peer-reviewed journal that covers all pharmaceutical sciences, including engineering, regulatory, physicochemical, biological, and microbiological studies related to the conception, design, production, characterization and . 1038/ s41598- 019- 51065-4. https:// doi. It is also called the science of dosage form design. International Journal of Pharmaceutical Sciences and Research (IJPSR) is an official publication of Society of Pharmaceutical Sciences & Research. Pharmacovigilance is a branch of pharmacology, relate to the collection, detection, assessment, monitoring and prevention of adverse effects or side effects of pharmaceutical products or formulations. Common routes of administration of drugs are through the mouth, skin, Trans mucosal and inhalation routes. Relative contraindication denotes that alert ought to be utilized when two medications or methodology are utilized together, it is worthy to do as such if the advantages exceed the danger. In order to improve the bottleneck of radiotherapy for glioma, people have done a lot of work; among this, nano-radiosensitizers have offered a novel and potential treatment method. 2015. The journal aims to publish novel research and review articles in the field of Pharmaceutical and Biological Sciences to reinforce the advancement of these areas which is not limited to: drug discovery, development, preformulation studies, drug delivery and targeting . 10. https:// doi. A prodrug must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent. Emerging Drugs are newly formed drugs used for disease treatment. The Journal of Pharmacy and Pharmacology is an official journal of the Royal Pharmaceutical Society, and one of the leading pharmaceutical sciences journals. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. org/ 10. The gene-loaded LPHNs-cRGD were successfully synthesized and could protect pCas9/MGMT from enzyme degradation. Targeted drug delivery system is a special form of drug delivery system where the medicament is selectively targeted or delivered only to its site of action, or absorption and not to the non-target organs or tissues. Impact factor: 0.89. clpt. 2016. Osler-Weber-Rendu syndrome (OWRD) is a rare vascular dysplasia of genetic origin and of autosomal dominant transmission, the pathophysiology of which involves the vascular endothelial growth factor (VEGF), a major growth factor of angiogenesis. 2147/ IJN. Pharmacology is subdivided into two categories as mentioned above, pharmacodynamics and pharmacokinetics. The mag.SLPs exhibited dose-dependent cytotoxicity against human leukemia cell lines growing in suspension (Jurkat and HL-60/wt), as well as the doxorubicin (Dox)- and vincristine-resistant HL-60 sublines. Pharmacovigilance is a type of pharmacological science which deals with the detection, assessment and prevention of adverse effects of drugs to get the safe and rational use of medicines. 2007. The entire drug medicament possesses the therapeutic effect. the hypothesis that efflux transporters influence brain pharmacokinetics/pharmacodynamics of molecularly targeted agents in glioma treatment, we assessed region-specific penetrance and molecular-targeting capacity for a PI3K/mTOR kinase inhibitor that has high substrate affinity for efflux transporters (GDC-0980) and an analog (GNE-317) that was purposely designed to have reduced efflux. 1016/j. Editorial Manager is an online manuscript submission, review and tracking system. Oxidation, hydration, reduction, hydrolysis are different kind of reactions by which a drug is metabolized. European Review for Medical and Pharmacological Sciences 2020 Impact Factor: 3.507 5-Year Impact Factor 3.111. 53. These conclusions were confirmed by Western blot analysis of apoptosis-related proteins, study of DNA fragmentation (DNA laddering due to the inter-nucleosomal cleavage and DNA comets due to single strand breaks), as well as by FACS analysis of the patterns of cell cycle distribution (pre-G1 phase) and Annexin V/PI staining of the treated Jurkat cells. Nanomaterials, with their one of kind size-subordinate physical and synthetic properties, have indicated promising focal points as medication and quality conveyance vehicles, ultra-delicate intracellular identifiers and novel helpful medications. Drug delivery refers to approaches, formulations, and transporting a drug compound in the body as needed to administer a safety and therapeutic effect. Of-late, the role of different microRNAs (miRNAs) in progression and proliferation of GBM was realized, which lead to their burgeon potential applications for diagnostic and therapeutic purposes. 1016/j. org/ 10. This process can either increase the drugs effect or my decrease the drug activity. Website: www.ijpsr.com Projected Impact Factor (2012): 2.44, ICV 2012: 5.50, 2011: 5.07, 2010: 4.57 DOI: 10.13040/IJPSR.0975-8232 SJ Impact Factor (2012): 3.226 Global . 1186/ s12951- 020- 00589-3, https:// doi. Advanced Pharmaceutical Bulletin: 16876342: Advances in Pharmacological Sciences: 14643502: Alcohol and Alcoholism: 15300277: Alcoholism: Clinical and Experimental Research: 21504296 : American Journal of Drug Discovery and Development: 15574970: American Journal of Pharmacology and Toxicology: 15363686: American Journal of Therapeutics: 19619480 more. nano. Advances in Pharmacological and Pharmaceutical Sciences publishes original research articles and review articles in all areas of experimental and clinical pharmacology, pharmaceutics, medicinal chemistry and drug delivery. 3109/ 10611 86100 35872 35, https:// doi. Drug Metabolism is said to be process by which the body breaks down and converts medication into active chemical substances. In accordance with Journal of Pharmaceutics & Drug Delivery Research's editorial policy, review content is not publicly displayed on Publons. 2015. 54. Molecular Modeling allows scientists to use computers to visualize molecules means representing molecular structures numerically and simulating their behavior with the equations of quantum and classical physics. delivery systems for tuberculosis prevention and treatment advances in pharmaceutical technology and numerous books collections from fictions to scientific research in any way. Drug targeting is the art of science where the drug delivery is aiming for delivery of the particular compound to a particular tissue or a part of the body. Publisher Impact Factor Indexed in 116 Indian Journal of Pharmaceutical Education & Research 0019-5464 APTI 0.15 Science Citation Index,SCOPUS, EMBASE, 117 International Journal of Pharmacy and Pharmaceutical sciences 0975-1491 Innovare Academic Sciences 1.1 PUBMED 118 International Journal of Pharmaceutical Sciences and . Among the various therapeutic strategies, nanomedicine-based immunotherapeutic systems represent a new era that can deliver useful cargo with promising pharmacokinetics. Drug Safety Information maintenance maintains periodic report preparation method so as to enable the surveillance and signal detection that allows for the delivery of greater patient safety. 2018. Advances in Pharmacological and Pharmaceutical Sciences is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of experimental and clinical pharmacology, pharmaceutics, medicinal chemistry and drug delivery. As a scientific journal it renders novel, clear connection to Pharmaceutical requirements and Pharmacological . Journal of Drug Metabolism & Toxicology, Drug Metabolism and Disposition, Current Drug Metabolism, Drug Metabolism Reviews, Expert Opinion on Drug Metabolism and Toxicology. Application of New Radiosensitizer Based on Nano-Biotechnology in the Treatment of Glioma, Gene Therapy for Drug-Resistant Glioblastoma via Lipid-Polymer Hybrid Nanoparticles Combined with Focused Ultrasound, Nanomedicine-based Immunotherapy for Central Nervous System Disorders, Magnetic Temperature-Sensitive Solid-Lipid Particles for Targeting and Killing Tumor Cells, Salinomycin-Loaded Iron Oxide Nanoparticles for Glioblastoma Therapy, Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery, Hypoxia-Responsive LipidPolymer Nanoparticle-Combined Imaging-Guided Surgery and Multitherapy Strategies for Glioma, Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment, Targeted delivery of miRNA based therapeuticals in the clinical management of Glioblastoma Multiforme, Gold Nanoparticles in Glioma Theranostics, LipidBased Nanocarriers for The Treatment of Glioblastoma, Immunoengineering in glioblastoma imaging and therapy. Increased brain penetrance correlated with decreased staining of activated p-Akt, p-S6, and p-4EBP1 effector proteins downstream of PI3K and mTOR. 1054/ bjoc. 05. When examined in an in vitro bloodbrain barrier (BBB)-GBM co-culture model, Sali-IONPs had limited penetration (1.0% 0.08%) through the bEnd.3 monolayer and resulted in 60% viability of U251 cells. 21, https:// doi. For permissions, please e-mail: journals.permissions@oup.com. Drug transport and delivery is integrated with dosage form and route of administration. Journal of Pharmaceutical Investigation(J. Pharm. Therapeutic Advances in Psychopharmacology, vol. Compared with conventional radiotherapy, nanotechnology can overcome the bloodbrain barrier and improve the sensitivity of glioma to radiotherapy. org/ 10. Furthermore, the upregulation of tumor suppressors (i.e., p53, Rbl2, Gas5) was observed, while TopII, Ku70, CyclinD1, and Wnt1 were concomitantly downregulated. The archive for this journal includes: Adv Pharmacol Pharm Sci: Vols. org/ 10. Drug therapy also referred to as pharmacotherapy, is a common terminology often used in the field of biomedical science as well as epidemiology. This book covers the recent innovations relating to various bioactive natural products (such as alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, volatile oils, fixed oils, Pharmaceutics encloses the non-scientific aspects such as how to make medications more palatable, where raw materials may be obtained, etc. Print. If X is the total number of articles published in 2015 and 2016, and Y is the number of times these articles were cited in indexed journals during 2017 then, impact factor = Y/X. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. This mode provides the means to maximize the visibility, citations and readership which enhance the impact of the research work and provides a range of options to purchase our articles and also permits unlimited Internet Access to complete Journal content. No. Journal of Pharmaceutical Sciences & Emerging Drugs is an international, best peer-reviewed, indexed hybrid journal which offers dual mode of publication, open access & subscription. Drug design is a splendid inventive process of new medication on the basis of biological target. Drug discovery is the process to identify new medications for bringing the disease to a safe and effective new treatment to patients. 1016/j. Advances in Pharmacological and Pharmaceutical Sciences - Table of contents. They are: Molecular. The salinomycin (Sali)-loaded PEI-PEG-IONPs (Sali-PEI-PEG-IONPs) released salinomycin over 4 days, with an initial release of 44% 3% that increased to 66% 5% in acidic pH. The ranking percentile of Advances in Pharmacological Sciences is around . Journal of In Silico & In Vitro Pharmacology bridges the gap between molecular modelling approaches and drug discovery by in silico pharmacological methods.It explains the use of this models to use in the discovery and optimization of novel molecules to a target, the clarification of absorption, distribution, metabolsm, elimination combinely called as pharmacokinetics and . Design new drug involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity, efficacy, metabolic stability and oral bioavailability. The journal welcomes submissions in all fields of experimental and clinical Read more All rights reserved. Select Journal*. Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities Maria Novella Romanelli, Vittoria Borgonetti, Nicoletta Galeotti November 2021 1038/ natur e11287, https:// doi. org/ 10. Staining of U251 cells with the fluorescent dyes Hoechst 33342 and propidium iodide (PI) revealed that mag.SLPs treatment resulted in an increased number of cells with condensed chromatin and/or fragmented nuclei as well as with blebbing of the plasma membranes. "The Pharmaceutical Society of Chosun" was founded in 1914 as a non-profit scientific society, and renamed in 1951 as "The Pharmaceutical Society of Korea". Drug stability is to maintain the physical, chemical, therapeutic and microbial properties during the time of storage and usage by the patient. This paper focuses on the research progress of nano-radiosensitizers in radiotherapy for glioma. Drug safety databases contain professional assessment of the potential of drugs. In contrast, the non-magnetic SLPs and neat iron oxides did not influence ROS levels significantly. Roland Ako is working in department of pharmacological and pharmaceutical sciences, College of Pharmacy, University of Houston, Moursund Street, Houston, USA. Drug metabolism mainly takes place in liver. Nanotechnology Approaches to Biology > Nanoscale Systems in Biology. Advances in Pharmacological and Pharmaceutical Sciences | Read 69 articles with impact on ResearchGate, the professional network for scientists. Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a P Drug delivery approaches for the treatment of glioblastoma multiforme. Biol. Bevacizumab is an anti-VEGF monoclonal antibody that has demonstrated its interest in this indication. Moreover, usNLCs were found to be well tolerated by mice and able to impair tumor growth in an orthotopic xenograft model, whereas for mice administered with the non-encapsulated therapeutic compounds, tumor growth exceeded 181% in the same period. Submit Manuscript. Rapid advances in our collective understanding of biomolecular structure and, in concert, of biochemical systems, coupled with developments in computational methods, have massively impacted the field of medicinal chemistry over the past two decades, with even greater changes appearing on the horizon.
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