The SJR is a size-independent prestige indicator that ranks journals by their 'average prestige per article'. Mater. Sci. Cyclic biaxial tensile strain promotes bone marrow-derived mesenchymal stem cells to differentiate into cardiomyocyte-like cells by miRNA-27a. Lee group proved that zirconia implants with acid-etched showed comparable osseointegration with Ti implants (Kuo et al., 2017). Part A 103, 32733283. 2 |2020 STEM CELLS PRIN T & DIGITAL MEDIA GUIDE. Hyaluronic acid hydrogels with IKVAV peptides for tissue repair and axonal regeneration in an injured rat brain. Endometrial regenerative cells: a novel stem cell population. 11, 45994613. The effect of nanotopography surface on bone regeneration was investigated by Yang C. et al. doi: 10.1016/j.ceramint.2013.07.092, Lin, W. J., Qin, L., Qi, H. P., Zhang, D. Y., Zhang, G., Gao, R. L., et al. Mater. Sci. Zhang X. et al.s (2019) group developed aligned all-cellulose nanofibers coated with bone morphogenetic protein-2 (BMP-2) via electrospinning. Natl. doi: 10.1016/j.biomaterials.2019.03.040, Rabkin, E., and Schoen, F. J. (2007). doi: 10.1002/jbm.a.32132, Zhang, H., Jia, X. L., Han, F. X., Zhao, J., Zhao, Y. H., Fan, Y. Sci. JGH Open 1, 153155. Photosensitive hydrogel creates favorable biologic niches to promotespinal cord injury repair. Med. doi: 10.1002/term.2842, Feng, C., Zhang, W., Deng, C., Li, G., Chang, J., Zhang, Z., et al. Eng. (2015). External citations are calculated by subtracting the number of self-citations from the total number of citations received by the journals documents. Additionally, exercise can strengthen bones (Niinimaki, 2012). Mater. Dermato. The summary of stem cell used in TERM is shown in Table 1. Chinas push in tissue engineering. doi: 10.1002/term.2130, Zhu, X., Cui, W., Li, X., and Jin, Y. (2016) prepared biomimetic composite hydrogel for bone repair composed of collagen and HAp; alendronate (ALN), an anti-osteoporosis drug, was also incorporated into this composite hydrogel. Genet. Three-dimensional zinc incorporated borosilicate bioactive glass scaffolds for rodent critical-sized calvarial defects repair and regeneration. In a study, it was demonstrated that fluid shear stress would affect cardiomyogenic differentiation of rat BMSCs (Huang Y. et al., 2010). 10, 51565168. doi: 10.1016/j.actbio.2016.08.023, Maeno, S., Niki, Y., Matsumoto, H., Morioka, H., Yatabe, T., Funayama, A., et al. Bioelectronics in Medicine. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. In a recent work, a multichannel poly(propylene fumarate) scaffold modifying with collagen-binding neurotrophic factor 3 promoted neural regeneration of SCI (Chen et al., 2018c). The increased investment by key market players in the research and development of the regenerative medicine is one of the major factor anticipated to drive the regenerative medicine market growth during the forecast period. Biodegradable metals such as magnesium (Mg) and its alloys have been attracting great attention in TERM due to their satisfactory mechanical property, biodegradation property, and bioactive effect. doi: 10.1007/s12272-013-0299-298, Esaki, S., Katsumi, S., Hamajima, Y., Nakamura, Y., and Murakami, S. (2019). Regenerative Medicine 11.3. doi: 10.1016/j.biomaterials.2010.08.011, Chen, L., Wang, D. H., Peng, F., Qiu, J. J., Ouyang, L. P., Qjao, Y. Q., et al. doi: 10.1016/j.actbio.2014.10.015, Zhao, T., Tan, M., Cui, Y., Deng, C., Huang, H., and Guo, M. (2014). In addition, Ta could still show unique mechanical properties even at high porosity (>80%), which allows rapid bone ingrowth (Alvarez and Nakajima, 2009). Mater. Non-covalent interaction cooperatively induced stretchy, tough and stimuli-responsive polyurethaneurea supramolecular (PUUS) hydrogels. Bionic cartilage acellular matrix microspheres as a scaffold for engineering cartilage. (2019) prepared aligned electrospun fibers of poly(L-lactide-co-caprolactone)/poly(L-lactic acid) (PLCL/PLLA) shellcore fibers via coaxial electrospinning and found that the stiffness of aligned fibers could regulate the phenotypic expression of vascular smooth muscle cells (VSMCs) (Yi et al., 2019). Impact Factor Calculations. Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair. Regenerative Medicine Impact Factor IF 2020|2019|2018 - BioxBio 3D printing is also a promising method to construct biomimetic vasculature for tissue regeneration. Cell sheet engineering and its application for periodontal regeneration. (2015). 69, 120130. doi: 10.1007/s00441-007-0419-411, Zhang, C., Wang, X. L., Zhang, E. C., Yang, L., Yuan, H. H., Tu, W. J., et al. Biomaterials 168, 3853. Cell culture on a thermo-responsive polymer surface. Highly aligned core-shell structured nanofibers for promoting phenotypic expression of vSMCs for vascular regeneration. Regenerative Medicine: applying tissue engineering, stem cell therapy, medical devices and other techniques to repair damaged or diseased tissues and organs. MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia. Enhancement of schwann cells function using graphene-oxide-modified nanofiber scaffolds for peripheral nerve regeneration. Due to the page limit, this review is far from being comprehensive; instead, we highlight here only a small fraction of important advances of TERM in Asia as examples. Res. doi: 10.1016/j.actbio.2006.11.002, Haraguchi, Y., Shimizu, T., Sasagawa, T., Sekine, H., Sakaguchi, K., Kikuchi, T., et al. Acta 1044, 2965. The preclinical and clinical outcomes of Xinsorb were further studied (Shen et al., 2017; Lv et al., 2018; Wu Y. (2019). The scaffolds are able to promote the biomineralization process and to stimulate the proliferation of rat BMSCs (Xie et al., 2019). Gao C. et al. Biomaterials 196, 122137. 25, 983993. This result showed that dynamic mechanical stimulus was helpful for the maturation of tissue-engineered tendon in vivo. Direct 3D bioprinting of perfusable vascular constructs using a blend bioink. Colloids Surf. Sci. One of the safety concerns for CRISPR technology is unforeseen genetic, which may bring unpredictable physiological changes or even death to patients. Adv. doi: 10.1002/jcp.22551, Shi, Y. C., Wang, L. T., Niu, Y. M., Yu, N., Xing, P. F., Dong, L., et al. (2019). Current heart transplantation therapy is still limited by lacking donors, suffering from chronic immunosuppressant therapy, and taking risks of subsequent development of graft vasculopathy (Stehlik et al., 2011). doi: 10.1016/j.gendis.2014.07.001, Zhang, E., Xu, L., Yu, G., Pan, F., and Yang, K. (2009). Sci. Organ-on-a-chip for cancer and immune organs modeling. Biomater. Part A 104, 19021911. doi: 10.1177/1545968311420444, Xue, C. B., Ren, H. C., Zhu, H., Gu, X. K., Guo, Q., Zhou, Y., et al. (2017) obtained electrospun cellulose/nano-HAp nanofibers, whose Youngs modulus and tensile strength were higher than commonly used polymer fibers such as PLA. Included are two leading journals devoted to publishing peer -reviewed articles, web-based platforms for up -to-the minute (2016). The story of bioglass. doi: 10.1016/j.actbio.2015.09.039, Zhu, L., Yang, J., Zhang, J., Lei, D., Xiao, L., Cheng, X., et al. Mater. doi: 10.1016/j.stem.2013.05.008, Gong, W. H., Lei, D., Li, S., Huang, P., Qi, Q., Sun, Y. J., et al. doi: 10.1039/c9bm00427k, Park, D. Y., Min, B. H., Lee, H. J., Kim, Y. J., and Choi, B. H. (2016). Successful nerve repair and functional recovery indicated the therapeutic effect of combining scaffolds and BMSCs. Med. In another study, transplantation of multilayered cell sheets composed of patients periodontal ligament derived MSCs was proved to promote regeneration of the periodontal and bone (Iwata et al., 2015). Sci. Yings group developed hydrodynamic spinning of gelatin-hydroxyphenylpropionic acid, alginate, poly(N-isopropylacrylamide), and polysulfone hydrogel fibers (Hu et al., 2010). Recellularized nerve allografts with differentiated mesenchymal stem cells promote peripheral nerve regeneration. (2016) determined the mechanism of CRISPR-Cpf1 system, by analyzing the structure of Acidaminococcus sp. As tissue engineering advances, new technologies, such as 3D printing and microfluidics, have attracted a lot of attention for preparing materials or scaffolds. The group of He fabricated 3D hydrogel-based vascular structures with macrochannels (Gao Q. et al., 2017). (2009). J. Vis. 52, 69076911. Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide. Mater. Mater. 4, 1399. doi: 10.1038/ncomms2406, Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., Yang, V. K., Cai, L., Wang, M., et al. Indian Heart J. Elastic deformation behaviour of Ti24Nb4Zr7.9Sn for biomedical applications. Interfaces 9, 1460614617. In addition, the scaffolds with different structures were also prepared for SCI repair. Biomaterials 35, 48884900. (2007a) focused on using temperature-responsive surfaces to harvest cell sheets, and their applications in corneal dysfunction, tracheal resection, esophageal cancer, and cardiac failure. doi: 10.1007/s00268-014-2740-2747, Igami, T., Nakamura, Y., Oda, M., Tanaka, H., Nojiri, M., Ebata, T., et al. doi: 10.1038/s41593-017-0060-66, Zhou, Q., Liu, Z., Wu, Z., Wang, X., Wang, B., Li, C., et al. This book is an essential resource for researchers, academics and professionals interested in the potential of nanostructured biomaterials for regenerative medicine. ACS Appl. Okuzu et al.s (2017) group investigated the effect of Mg ions released from MgTi alloy on MC3T3-E1 cell proliferation and osteogenic differentiation, and the results showed that MgTi could promote early bone healing. We used the Wed Web of Science database to search for original articles on the topics of Bone, cartilage, tendon/ligament, cardiovascular, nerve, skin, intervertebral disc, urethra, bladder, cornea, and regeneration published between 2009 and August 2019 inclusively. 112:13354. doi: 10.1073/pnas.1510194112, Yao, C. H., Chen, K. Y., Chen, Y. S., Li, S. J., and Huang, C. H. (2019). doi: 10.1016/j.ihj.2016.01.009, Miyazaki, T., Nakamura, T., Matsumura, H., Ban, S., and Kobayashi, T. (2013). Acta Biomater. Gingiva-derived mesenchymal stem cell-extracellular vesicles activate schwann cell repair phenotype and promote nerve regeneration. (2018) used an in situ forming corneal stromal substitute based on collagen type I, after encapsulating keratocytes; this substitute exhibited surface epithelialization with multilayered morphology when implanted to rabbit corneas in an organ culture model after keratectomy. 05, 4955. The journal is archived in Portico and via the LOCKSS initiative, which provides permanent archiving for electronic scholarly journals. (2018a). Mater. (2019) conjugated biocompatible carbon dot nanoparticles onto collagen to prepare an injectable hydrogel. Discussion on current limitations and future directions in this hot topic will also be provided. Role of hydroxyapatite nanoparticle size in bone cell proliferation. Mater. Mater. Flexible and microporous chitosan hydrogel/nano ZnO composite bandages for wound dressing: in vitro and in vivo evaluation. Repair of nerve defect with acellular nerve graft supplemented by bone marrow stromal cells in mice. doi: 10.1111/j.1525-1594.2012.01461.x, Li, J., Wang, J., Zou, Y., Zhang, Y., Long, D., Lei, L., et al. doi: 10.1007/s00776-013-0510-512, Kurakawa, T., Kakutani, K., Morita, Y., Kato, Y., Yurube, T., Hirata, H., et al. doi: 10.1016/j.tmrv.2015.11.004, Frey, B. M., Zeisberger, S. M., and Hoerstrup, S. P. (2016). doi: 10.1002/micr.20488, Fan, X., Chen, K., He, X., Li, N., Huang, J., Tang, K., et al. The chart shows the ratio of a journal's documents signed by researchers from more than one country; that is including more than one country address. Acad. 9, 12591267. Med. Physiol. Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface. (2018). 6, 20282034. 88, 540553. The 3D bioprinting of cells, growth factors, and hydrogels is mainly based on laser (Ali et al., 2014), droplet (Cui et al., 2014), and extrusion (Iwami et al., 2010) bioprinting. Biomater. The expression of Runx2 was reported to gradually increase under strain stimulation (Li C. J. et al., 2015; Li R. et al., 2015). Okanos group successfully regenerated cornea in rabbit by transplanting corneal epithelial cell sheets prepared with automated cell culture system (Kobayashi et al., 2013). Peng and Wangs groups used a neurotrophic peptide-functionalized, self-assembling nanofiber hydrogel to produce a neurotrophic microenvironment (Lu et al., 2018). (2017). Cell sheet tissue engineering: cell sheet preparation, harvesting/manipulation, and transplantation. (2011). Drug Discov. doi: 10.1016/j.actbio.2009.12.033, Yi, B., Shen, Y., Tang, H., Wang, X., Li, B., and Zhang, Y. The urinary stem cells possess robust proliferative potential and multi-potent differentiation potential (Zhang D. et al., 2014). They also added the mineralized collagen into poly(methyl methacrylate) (PMMA) bone cement (Li T. et al., 2015). doi: 10.1021/acs.nanolett.5b04043, Li, T., Weng, X. S., Bian, Y. Y., Zhou, L., Cui, F. Z., and Qiu, Z. Y. 8, 341349. However, the oral environment will cause corrosion of metallic restorations and generation of metal ions. doi: 10.1016/j.actbio.2019.02.024, Yang, J. B., et al. Exploring innovative solutions to improve the healthcare of the aging and diseased population continues to be a global challenge. They also combined different cells, including BMSCs (Zhao et al., 2011), BMSC-containing fibrin glue (Zhao Z. et al., 2014), and Schwann cell-like cells derived from ADSCs or BMSCs (Wang Y. et al., 2012), with acellular nerve grafts to repair nerve injury. (2019). Regen. Eng. doi: 10.1021/acsami.8b11714, Liu, S., Jiang, L., Li, H., Shi, H., Luo, H., Zhang, Y., et al. (2019b). Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field. In another report, they modified the tendon ECM into a random-aligned-random composite, and the results showed that the biomimetic tendon ECM composite enhanced the bone and fibrocartilage formation in the interface (Liu H. H. et al., 2017). This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). (2017). (2017) prepared cardiac muscle strips by encapsulating cardiomyocytes derived from human embryonic stem cells in collagen-based biomaterials. Aligned nanofibers direct human dermal fibroblasts to tenogenic phenotype in vitro and enhance tendon regeneration in vivo. This strategy provided a method that has a lower cost than the current soft prostheses fabrication methods (He et al., 2014). Cross-linked Collagenchondroitin sulfatehyaluronic acid imitating extracellular matrix as scaffold for dermal tissue engineering. Int. Int. This encapsulated E. coli may be used in biotransformation, bioremediation, biosensing, and artificial cells. Wangs group fabricated engineered lamellar cornea by seeding genetically modified embryonic stem cells and corneal epithelial cells on decellular porcine corneal stroma and amniotic membrane (Zhou Q. et al., 2014). 15, 547557. 278, 152157. J. Biomed. Bioactive glass, with a typical composition of 46.1% SiO2, 26.9% CaO, 24.4% Na2O, and 2.6% P2O5, is the first biomaterial that is able to bond to bone (Hench, 2006). Reactive macromolecular micelle crosslinked highly elastic hydrogel with water-triggered shape-memory behaviour. Physiol. doi: 10.1016/j.msec.2019.01.050, Lee, S. H., Bae, E. B., Kim, S. E., Yun, Y. P., Kim, H. J., Choi, J. W., et al. This unique form of mechanical force is regulated in real time by a variety of factors, such as exogenous force, motor proteins, osmotic pressure, mechanosensitive ion channels, intracellular mechanosensors, and actin assembly. U. S. A. (2016). (2014). The injectable HA hydrogel, fullerenol/alginate hydrogel, and oligo(poly(ethylene glycol)fumarate) hydrogel, which could deliver stem cells or some therapeutic drugs, helped the treatment of myocardial infarction and were also developed (L et al., 2009; Wang H. et al., 2012; Hao et al., 2017). doi: 10.1002/ajpa.22023, Nishida, K., Yamato, M., Hayashida, Y., Watanabe, K., Maeda, N., Watanabe, H., et al. Concise review: laying the groundwork for a first-in-human study of an induced pluripotent stem cell-based intervention for spinal cord injury. Biomaterials 192, 6274. J. Appl. doi: 10.1039/c8nr09818b, Zhang, Y., Zhu, D. S., Wei, Y. doi: 10.1111/j.1600-0560.2008.01020.x, Li, H., Chu, Y., Zhang, Z., Zhang, G., Jiang, L., Wu, H., et al. ACS Appl. Assembly of bone marrow stromal cell sheets with knitted poly (L-lactide) scaffold for engineering ligament analogs. (2009). Ther. Cell Tissue Bank. Ruszymahs group incorporated Zn oxide nanoparticles into chitosancollagen porous scaffolds, and the results showed that the incorporation of Zn oxide nanoparticles could both enhance the mechanical property and biocompatibility of porous scaffold (Ullah et al., 2017). Biomaterials 29, 36833692. Preparation of dexamethasone-loaded biphasic calcium phosphate nanoparticles/collagen porous composite scaffolds for bone tissue engineering. doi: 10.1016/j.biomaterials.2015.11.059, Li, H.-H., Fu, X.-B., Zhang, L., and Zhou, G. (2008). Kim et al. (2019). J. Clin. Surface modification is used to further improve the bioactivity of Ti alloys. doi: 10.1089/ten.tea.2010.0633, Yang, Z., Xie, H., and Li, T. (2000). U.S.A. 112, 1445214459. A controlled double-duration inducible gene expression system for cartilage tissue engineering. For topics on particular articles, maintain the dialogue through the usual channels with your editor. Within a Chem. (2014). Plast. doi: 10.1089/neu.2018.5835, Liu, W., Yin, L., Yan, X. R., Cui, J. H., Liu, W. G., Rao, Y., et al. doi: 10.1002/elps.201600386, Yan, Y. F., Cheng, B. C., Chen, K. Z., Cui, W. G., Qi, J., Li, X. M., et al. Biomaterials 162, 2233. Repair of thoracic spinal cord injury by chitosan tube implantation in adult rats. Mechanical stimuli have been shown to affect the gradient of nutrient and ion, pH, cell deformation, bioactivity, and synthesis of ECM components or growth factor (Bleuel et al., 2015). A variety of fibrous scaffolds were also used in neural tissue engineering (Li Y. et al., 2019; Ye et al., 2019a). doi: 10.1016/j.cell.2010.07.002, Igami, T., Nakamura, Y., Hirose, T., Ebata, T., Yokoyama, Y., Sugawara, G., et al. doi: 10.1038/nbt1374, Nakahata, M., Takashima, Y., Yamaguchi, H., and Harada, A. Development of tissue scaffolds using selective laser sintering of polyvinyl alcohol/hydroxyapatite biocomposite for craniofacial and joint defects. Mater. Adv. 23, 557559. Ther. They found that the pore structure and mechanical property also regulate cartilage regeneration (Chen S. et al., 2015). 36, 4445. All previously published articles are available through the Table of Contents. Interfaces 7, 1396013971. Z., Wu, Y. F., Zhao, R. X., Zhang, K. Y., Midgley, A. C., Kong, D. L., et al. Hiromotos group used octacalcium phosphate and HAp coatings to control the degradation speed and to improve the biocompatibility of biodegradable Mg alloys (Hiromoto and Yamazaki, 2017). The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells. Eng. (2015). Regenerative Medicine Market Overview Market Research Future (MRFR) studied the global regenerative medicine market 2020 can expand at about 25.4% CAGR across 2016 to 2022. 25, 113. Indexing & Abstracting . A., Sun, H., Su, J., Lin, N., Pault, B., et al. Mater. Acs Nano 11, 57375745. Proc. In addition, the direct in vivo reprogramming approach, which is reported simple, has a lower risk of tumor formation and avoids cell transplantation as proposed by Asian scholars. Mater. C-Mater. All previously published articles are available through the Table of Contents. Guss group has long contributed to use biomaterials for peripheral nerve regeneration (Gu X. et al., 2014). Eng. In situ tissue regeneration through mobilizing endogenous cell has been widely investigated. (2015). International J. Cardiovasc. A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection. We apologize to anyone whose work was not mentioned due to limited space. Gohs group prepared different silk-based scaffolds for TERM (Shi et al., 2013; Teh et al., 2013). J. Biomed. (2019). (2016). Biol. 28:1802642. doi: 10.1002/adfm.201802642, Kang, H., Zhang, K., Wong, D. S. H., Han, F., Li, B., and Bian, L. (2018b). 5, 474488. (2013). (2015). Anat. 38, 31633166. This method was applied in many tissues including adipose, cartilage, and heart. (2015). Moreover, the elasticity and biocompatibility of this adhesive were better than those of cyanoacrylate glue (Deng et al., 2019). Acta Biomater. In constructing this review, we retrieved a large number of literature and selected some representative works that are presented in this review. 32, 170177. Encyclopedia of Tissue Engineering and Regenerative Medicine, Three Volume Set provides a comprehensive collection of personal overviews on the latest developments and likely future directions in the field. Nishimuras group revealed that neuronal PAS domain 2 modified on the rough surface of Ti implant could facilitate osseointegration through neuroskeletal regulatory pathways (Morinaga et al., 2019). Part A 19, 13601372. Chem. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. The Journal of Molecular Medicine publishes original research articles and review articles that range from basic findings in mechanisms of disease pathogenesis to therapy. Impact Factor: 2.512 (2020) Personalised Medicine welcomes unsolicited article proposals. Being one of the important components in bone and teeth, calcium phosphate-based materials have attracted substantial attention in TERM (Wu et al., 2011). 63, 369382. ISSN (print): 1741-0541 | ISSN (online): 1744-828X. (2013). Lis group developed a neurotrophin-3 (NT-3)-containing chitosan-based scaffold, which could promote axon regeneration and functional recovery of SCI or brain injury (Li et al., 2009; Mo et al., 2010). PLoS One 10:e0132705. Sustainable dual release of antibiotic and growth factor from pH-responsive uniform alginate composite microparticles to enhance wound healing. The two years line is equivalent to journal impact factor (Thomson Reuters) metric. Stem Cell Rep. 1, 235247. Methods: We summarize the recent updates from a talk given to the scientific community about the . 1, 817. Park and Kims groups coated a Zn oxide/polylactic acid (PLA) nanocomposite layer on Mg alloys; this method could not only control the degradation rate but also control the surface topography of Mg alloys substrate (Mousa et al., 2018). Esaki et al.s (2019) group reported that transplantation of olfactory stem cells with biodegradable gelatin sponge could accelerate facial nerve regeneration after crush injury. Adipose mesenchymal stromal cells: definition, immunomodulatory properties, mechanical isolation and interest for plastic surgery. doi: 10.1016/j.biomaterials.2005.04.023, Qiu, J. J., Qian, W. H., Zhang, J. K., Chen, D. F., Yeung, K. W. K., and Liu, X. Y. Med. Acta Biomater. doi: 10.1016/j.snb.2018.11.025, Shi, M., Zhang, H., Song, T., Liu, X. F., Gao, Y. F., Zhou, J. H., et al. Inflammation and Regeneration provides an open access forum which covers a wide range of scientific topics in the research field of basic and clinical regenerative medicine. (2018). Sci. 17:3780. doi: 10.1039/b705129h, Cai, Z., Gan, Y., Bao, C., Wu, W., Wang, X., Zhang, Z., et al. The mechanical property of this scaffold could be controlled by changing porosity. (2019). Appl. The flexibility of microfluidic technology allows the preparation of multi-structured fibers such as hollow, multilayer, grooves, etc. The highest Journal Impact IF of npj Regenerative Medicine is 8.6. doi: 10.1002/jbm.a.35990, Dewi, A. H., Ana, I. D., Wolke, J., and Jansen, J. Interfaces 9, 1689016899. doi: 10.1038/s41596-018-0051-54, Yuan, H., Qin, J., Xie, J., Li, B., Yu, Z., Peng, Z., et al. (2007). Funct. Gus group found that chitosan/silk fibroin scaffold combined with allogeneic bone marrow mononuclear cells could facilitate nerve regeneration, and the scaffold can improve macrophage-constructed microenvironments (Yao et al., 2016; Zhao Y. H. et al., 2017). (2017) developed a biocompatible and antibacterial coating for PEEK using PDA-based surface modification technology and subsequent deposition of silver nanoparticles, which permits its potential use as an orthopedic material. With this method, Zeng and Zhous labs first generated several iPS cell lines that could meet the most stringent criteria for pluripotent stem cells and maintained a pluripotent potential close to embryonic stem cells (Zhao et al., 2009). doi: 10.1016/j.ymeth.2015.08.015, Prakash, J., Kumar, T. S., Venkataprasanna, K. S., Niranjan, R., Kaushik, M., Samal, D. B., et al. This Sr-NBC showed excellent biocompatibility and high odontogenic potential in vitro and more new dentin formation in vivo (Mandakhbayar et al., 2019). Adipose-derived stem cells modified genetically in vivo promote reconstruction of bone defects. Organs 36, 911919. 93, 204230. Imaging 33, 14731481. They also found that controlled release of collagen-binding stromal cell-derived factor-1 (SDF-1) from the scaffold promoted tendon regeneration in a rat Achilles tendon defect model (Sun J. et al., 2018). doi: 10.1016/j.carbpol.2019.02.038, Zhang, X. (2018) fabricated robust and biocompatible hydrogels via hostguest interaction. Sci. Sci. Biomaterials 30, 11211132. Part B Rev. Mater 29, 1700171. doi: 10.1002/adma.201700171, Cheng, Y., Yu, Y., Fu, F., Wang, J., Shang, L., Gu, Z., et al. Med 8:E1831. Natl. The results showed that the dynamic mechanical compression enhanced cell viability and upregulated the expression of Sox-9, collagen II, and aggrecan in the absence of exogenous growth factors. doi: 10.1016/j.drudis.2014.04.010, Sivaraj, D., and Vijayalakshmi, K. (2019). (2019). The highest Journal Impact IF of Regenerative Medicine is 3.873. Tissue engineering and regenerative medicine has been proposed and developed for more than 30 years. In the ear reconstruction field, bioprinting is also widely used. J. (2012). (2018). (2014). Around USD 13.3 Bn global financing were raised in 2018 by investment into regenerative medicine. Mater. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. The 2020-2021 Journal Impact IF of npj Regenerative Medicine is 8.6, which is just updated in 2021. (2017). Tissue engineering and regenerative medicine - new initiatives for individual treatment offers. Part A 105, 10551062. J. Cutan. Mater. A cell-laden and orthogonal-multilayer tissue-engineered corneal stroma facilitated the construction of physiological feature tissue-engineered corneal stroma and helped to reverse fibrosis pathologies in general (Cui et al., 2018). Res. doi: 10.7150/thno.23674, Deng, D., Wang, W. B., Wang, B., Zhang, P. H., Zhou, G. D., Zhang, W. J., et al. Cardiac stem cell therapy and the promise of heart regeneration. doi: 10.1021/acsbiomaterials.6b00643, Garbern, J. C., and Lee, R. T. (2013). Calcium phosphate nanoparticles with various sizes and shapes are also synthesized and applied in the area of tissue engineering (Lin K. et al., 2014). doi: 10.1177/0363546518815151, Park, Y. 120:55018. doi: 10.3791/55018, Pineda, M., Lear, A., Collins, J. P., and Kiani, S. (2019). Progress in 3D bioprinting technology for tissue/organ regenerative engineering. doi: 10.1016/j.biomaterials.2017.02.026, Zhao, Z., Wang, Y., Peng, J., Ren, Z., Zhan, S., Liu, Y., et al. (2014). (2017). Adv. doi: 10.1073/pnas.1304053110, Wang, C. Y., Feng, N. B., Chang, F., Wang, J. C., Yuan, B. M., Cheng, Y. L., et al. In the clinic, allogeneic MSCs from bone marrow or umbilical cord have been evaluated in cartilage defect, SCI, corneal injuries, cardiomyopathy, IVD degeneration, and bone defect with an excellent safety profile. Surgical repair of a 30 mm long human median nerve defect in the distal forearm by implantation of a chitosanPGA nerve guidance conduit. Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: in vitro simulation of the bone-repairing effect of Mg-based alloy implant. Likewise, growth factors such as BMP-2 and TGF-1 and vascular endothelial growth factor (VEGF) are also introduced to scaffolds to enhance bone repair (Qu et al., 2015; Yan et al., 2016). (2012). Using a composite of allogeneic umbilical cord blood-derived MSCs and hyaluronate hydrogel, regenerated articular cartilage in the defects of patients was observed (Park Y.
Microsoft Word Definitions List, Closure And Implementation In Negotiation Process, Sbac Testing Ct 2021 Results, Visionary Scholarship, Motivational Safety Speeches, Colorado Missing Persons List, Bless This House Sign, Prisma Health Emergency Physicians Richland,